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DHRHealth Institute for Research and Development

Clinical Trial

Multi-Arm Optimization Of Stroke Thrombolysis (MOST): A Single Blinded, Randomized Controlled Adaptive, Multi-Arm, Adjunctive-Thrombolysis Efficacy Trial In Ischemic Stroke.

Study Status:

Study Closed

Contact Information:

(956) 362-2391

Please contact us for more information or to learn if you are eligible to participate.

Study Purpose:

The purpose of the MOST study is to determine whether argatroban and/or eptifibatide is superior to placebo in improving 90-day modified Rankin scores (mRS) in acute ischemic stroke (AIS) patients treated with IV rt-PA (0.9mg/kg) or TNK (0.25mg/kg) within three hours of symptom onset.


Principal Investigator
Patricia Fernandez, M.D.
Esmeralda Cordoso-Mendoza
Washington University School of Medicine / National Institute of Neurological Disorders and Stroke (NINDS)
Type of Trial
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